The family of one of Spider-Man's greatest foes is wreaking havoc across the universe.

The Venom symbiote puts Peter Parker, Eddie Brock, and Flash Thompson through the ringer, leaving Spider-Man caught between Eddie and the mysterious Black Cat.

While Spider-Man deals with a Doctor Octopus back from the dead, Scarlet Spider faces off against Carrion, and the Jackal unveils a twisted plan.

As Parker Industries gains global success, Peter Parker's alter ego gets some upgrades of his own, along with back-up from Nick Fury and Mockingbird as he tackles a series of international threats.

Dan Slott brings his spectacular decade-long run as the Amazing Spider-Man writer to a blockbuster finish by combining two of the wall-crawler's greatest foes into one unstoppable killing machine! Norman Osborn has been scouring the globe for a source of power with which he can exact his final revenge on Peter Parker--and he's about to find it! But when Osborn bonds with the Carnage symbiote, he'll no longer be the Green Goblin--he'll be something new. With all the strengths of both villains, but none of the weaknesses, he takes to the skies as the Red Goblin! And now none of Peter's friends or family are safe. Spidey is in for the fight of his life as Slott signs off in exhilarating, emotional style!

Eddie Brock, the symbiote known as Anti-Venom, is trying to find his place in the world, somewhere between the dark and the light, but his decision is complicated when he runs into the Punisher, who does not know Eddie has turned over a new leaf.

"What will Secret Empire mean for the Amazing Spider-Man? The return of Otto Octavius! But this isn't the old Doc Ock - he's back as the Superior Octopus! He's allied himself with Steve Rogers and Hydra, and he has a personal mission - to take down the company that he helped create: Parker Industries! Spider-Man is already overwhelmed from the chaos of Secret Empire - but now, facing one of his greatest enemies who's back from the grave, more powerful than ever before and following orders from Captain America himself, does Spider-Man stand a chance? Peter must use the full force of his company, every asset at his disposal, to stop Ock and Hydra - but will it be enough?" --

The end of Spider-Man's world begins, when the dying Doctor Octopus discovers who Peter Parker really is!