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Welcome to Stillwater, a quiet town nestled on the banks of the Illinois River. Twelve years ago, Frankie Stapleton moved to Chicago, leaving behind her family, their struggling hardware store, and her fiance. Now she s back--an emergency room nurse with an adrenaline addiction and a string of failed engagements--to help her pregnant sister, Charlie, and to put the past behind her, once and for all. But within minutes of arriving at Stillwater General Hospital, Frankie walks into an ER overloaded with a busload of crash victims. Amidst the chaos, she stumbles upon a lone man suffering a cardiac arrest outside the ER bay. With no one to spare him a passing glance, Frankie acts to save the man's life, despite the fact that she's not licensed at Stillwater Gen and her priorities "should" lie with her sister, whose pregnancy has taken a dangerous turn up in the maternity ward.