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In 1812, as the fledgling United States is drawn into war, the fate of the far west hinges on Manuel Lisa and his trading expedition up the Missouri River. An intimate of the Burr conspiracy, the condemned John Tylor, signs on as boatman. But lurking in Tylor's shadow is half-mad Fenway McKeever. Paid to kill Tylor, he plans to destroy Lisa's expedition and sell his services to the highest bidder.