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In 1974, a young doctor arrived at the Centers for Disease Control and Prevention with one goal in mind: to help eradicate smallpox. The only woman physician in her class in the Epidemic Intelligence Service, a two-year epidemiology training program, Mary Guinan soon was selected to join India's Smallpox Eradication Program, which searched out and isolated patients with the disease. By May of 1975, the World Health Organization declared Uttar Pradash smallpox-free.During her barrier-crossing career, Dr. Guinan met arms-seeking Afghan insurgents in Pakistan and got caught in the cross fire between religious groups in Lebanon. She treated some of the first AIDS patients and served as an expert witness in defense of a pharmacist who was denied employment for having HIV -- leading to a landmark decision that still protects HIV patients from workplace discrimination.