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"An extraordinary, eye-opening book." - People 2018 National Health Information Awards, Silver Award "A rousing wake-up call . . . this highly engaging, provocative book prove[s] beyond a reasonable doubt that millions of lives depend on us finally coming to terms with the long-term consequences of childhood adversity and toxic stress." - Michelle Alexander, author of The New Jim Crow Dr. Nadine Burke Harris was already known as a crusading physician delivering targeted care to vulnerable children. But it was Diego - a boy who had stopped growing after a sexual assault - who galvanized her journey to uncover the connections between toxic stress and lifelong illnesses. The stunning news of Burke Harris's research is just how deeply our bodies can be imprinted by ACEs - adverse childhood experiences like abuse, neglect, parental addiction, mental illness, and divorce.