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2010 had been a very good year for Bruce H. Kramer. But what began as a floppy foot and leg weakness led to a shattering diagnosis he had amyotrophic lateral sclerosis. ALS is a cruel, unrelenting neurodegenerative disease where the bodys muscles slowly weaken, including those used to move, swallow, talk, and ultimately breathe. There is no cure ALS is a death sentence.When death is a constant companion, sitting too closely beside you at the dinner table, coloring your thoughts and feelings and words, your outlook on life is utterly transformed. The perspective and insights offered in We Know How This Ends reveal this daily reality and inspire a way forward for anyone who has suffered major loss and for anyone who surely will. Rather than wallowing in sadness and bitterness, anger and denial, Kramer accepted the crushing diagnosis.