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Dr. Jessie Drake, in her mid-sixties, following the sudden deaths of her parents and Kat, her partner of twenty years, has fled the Vermont life she has known for decades.In an effort to escape the oppressive constancy of grief, she accepts a job from an old flame from her residency in New York City's Roosevelt Hospital, and agrees to assist Ben as the ship's doctor on a British liner. Jessie boards in Hong Kong, and, as the Amphitrite sails throughout Southeast Asia and the Middle East, cruise ship antics ensue. Jessie is lulled back into a long-ago romance with the ship's co-doctor, and both she and her new/old beau become enmeshed with the ship's lead (female) singer/entertainer. Among the passengers who fling socialized behavior aside on the high seas: a former Florida beauty queen (Miss Florida Power and Light) on a second honeymoon with her husband, as she causes high-velocity scandal, while juggling onboard affairs with a suicidal golf pro, and a defrocked priest hired as one of the liner's gentleman hosts, until she vanishes--poof!--from the ship off the coast of Portugal .