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Carrie Pilby (Bel Powley) is a 19-year old genius, a year out of Harvard, living in New York City. Burdened with an overactive moral compass in a world she considers to be populated by oversexed, deceitful hypocrites, Carrie finds herself isolated, friendless, dateless and unemployed. When Carrie's absentee father (Gabriel Byrne) insists she get a roommate or a job, and her psychiatrist (Nathan Lane) , makes a list of goals she is to achieve between Thanksgiving and the end of the year, Carrie resists the mundane until her goal-oriented brain forces her to embrace these tasks with a vengeance. Others who unwittingly help Carrie achieve her goals include Cy (William Moseley) , her didgeridoo-playing musical prodigy neighbor; engaged and confused Matt (Jason Ritter) who sincerely believes that cheating will bring him clarity; Carrie's former Harvard professor Harrison (Colin O'Donoghue) , the genesis of everything Carrie hates; and new boss Tara (Vanessa Bayer) , who convinces Carrie that it's not her job to be the moral guardian of the human race.

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