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All ten episodes of the award-winning medical drama series' second season, set in 1901, is available in this collection. Dr. John Thackery (Clive Owen) continues to perform cutting-edge operations, including an electrical brain stimulation and a devised procedure to seperate conjoined twins, all while battling a heroin addiction that is becoming increasingly dire. Meanwhile, the gifted Dr. Algernon Edwards (Andre Holland) , who has ascended to the role of acting chief of surgery, continues to face racially-charged disrespect while dealing with the reappearance of his strong-willed wife, Opal (Zaraah Abrahams) . Subplots include Nurse Elkins' (Eve Hewson) search for personal and professional fulfillment, a fiery, near-death experience and various other events in and out of Knickerbocker Hospital with grave consequences. All ten episodes are directed by Academy Award-winning director Steven Soderbergh.

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