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If you want to acquaint yourself with Sherlock Holmes and Dr. John Watson, you should really start at the beginning. Doyle’s characters are still taking shape in this first tale, but it’s truly essential to set up the rest of the stories. In it, we learn how the pair came to meet and work together, and are introduced to Sherlock’s idiosyncratic ways. Followed by: The Sign of Four The Adventures of Sherlock Holmes The Memoirs of Sherlock Holmes