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The brilliant and irreverent Dr. Mark Sloan (Dick Van Dyke) is still solving murders with the help of his homicide detective son Steve (Barry Van Dyke) , pathologist Dr. Amanda Bentley (Victoria Rowell) and E.R. resident Dr. Jesse Travis (Charlie Schlatter) . But this season the series takes some surprising and inventive turns in 22 ingenious episodes that play with the conventions of the mystery genre and that explore Dr. Sloans past, the psychological reasons behind why he solves murders, and his complex relationship with his son.

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