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In the words of They Might Be Giants' rollicking Grammy-winning theme song, "life is unfair." The inventive and wholly original sitcom Malcolm in the Middle has been honored with a Peabody Award and Emmys for directing and writing, but if life was fair, it would have earned an Emmy for Best Comedy Series, not to mention statuettes for its pitch-perfect cast. With his perpetual "yes, me worry" expression, Frankie Muniz instantly earns audience empathy as Malcolm, whose chances for a normal life are thwarted not only by his genius IQ (as discovered in the pilot episode), but also by his outrageously dysfunctional family: Lois (Jane Kaczmarek), his obsessive, control-freak mother; Hal (Bryan Cranston), his loving but ineffectual father; Francis (Christopher Masterson), his eldest brother waging his own private war at military school; middle brother Reese (Justin Berfield), a delinquent savant; and Dewey (Erik Per Sullivan), the put-upon youngest.

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